Bioinformatics has been
one of the most fast-developing fields in scientific research. As an important
tool in bioinformatics, microarray technology was
developed in great need. It provides a remarkable tool to monitor the expression
level of a large amount of genes. The biological techniques to measure DNA,
however, are limited in their efficiency in time and expense. As a technology
combining biological knowledge and electronic technique, microarray
is able to measure a large quantity of DNA simultaneously. Following is a
brief introduction of the methodology of microarray.
Firstly, cells from different tissue or different source are treated with
different conditions before biological digestion. After that, mRNAs which
are extracted from different treatment conditions are hybridized with microarray
chip. The intensity of the fluorescence on the chip will represent the expression
level of the gene on the spot.
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